Lyme disease (Lyme borreliosis) is a common infectious disease that is transmitted to humans from these animals that carry the disease as a result of the bites of ticks. The disease is caused by the bacteria of the genus Borrelia, which is from the Spirochete group. The disease is first manifested by rashes in the area where the ticks bite. Afterwards, a systemic involvement develops as the organs are affected.
“HLA association with antibiotic-resistant Lyme borreliosis” :
DR4 (DRB1*04:01, 04:02)
“HLA association with antibiotic-sensitive Lyme borreliosis” :
DR11 (DRB1*11:01, *11:04)
“HLA association in patients with a decreased formation of borrelia-specific antibodies in spite of an identified borrelia infection”:
DR1 allele (DRB1*01:02, *01:01,*01:04, *01:05)
HLA association with strong seropositive borreliosis:
DR7 (DRB1*07:01, *07:03, *07:04)
Material and requirements
2 ml EDTA blood (blood count test tubes) are needed.
The laboratory requirement is: HLA-DR subtyping in borreliosis.
Transport of the blood sample to the laboratory is not time critical and can be done by mail. For genetic testing, we require the signed consent of the patient.